Phkg2 ferroptosis

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August undefined, 2024

Webb1 jan. 2024 · Ferroptosis is an iron-dependent non-apoptotic cell death that can elicited by pharmacological inhibiting the cystine/glutamate antiporter, system Xc − (type I) or directly binding and loss of activity of GPx4 (Type II) in cancer cells with high level RAS-RAF-MEK pathway activity or p53 expression, but not in normal cells. Webb2 dec. 2024 · Ferroptosis is a newly discovered type of programmed cell death that, in an iron-dependent manner, peroxidizes unsaturated phospholipids and results in the …

PHKG2 regulates RSL3-induced ferroptosis in Helicobacter pylori …

Webb31 aug. 2024 · A ferroptosis-related gene signature for overall survival prediction and immune infiltration in lung squamous cell carcinoma A ferroptosis-related gene … Webb24 nov. 2024 · PHKG2 encodes a subunit of phosphorylase kinase, and the knockdown of PHKG2 inhibits ferroptosis induced by erastin . In our study, five of these genes … cisco networking wallpaper

Frontiers Ferroptosis-Related Gene Signature Accurately Predicts ...

WebbWe identified a novel ferroptosis-related ten-gene signature (PHKG2, PGD, PEBP1, NCOA4, GLS2, CISD1, ATP5G3, ALOX15, ALOX12B, and ACSL3) that can accurately predict LUAD … Webbferroptosis inducers inhibit GPX4 by covalently targeting the active site selenocysteine, leading to accumulation of PUFA hydroperox-ides. In summary, we found that PUFA oxidation by lipoxygenases via a PHKG2-dependent iron pool is necessary for ferroptosis and that the covalent inhibition of the catalytic selenocysteine in Gpx4 Webb22 dec. 2024 · Phosphorylase kinase G2 (PHKG2) can regulate iron availability of lipoxygenase, including arachidonate LOX12 (ALOX12), ALOX12B, ALOX15, and … cisco networking simplified

Small Molecule Regulators of Ferroptosis SpringerLink

National Center for Biotechnology Information

Webb28 juni 2024 · Ferroptosis is a new type of iron-dependent programmed cell death. In recent years, its role in the diagnosis and treatment of multiple tumors, including non … Webb3 feb. 2024 · Ferroptosis is a newly identified iron-dependent cell death that is different from other cell death forms, including apoptosis and necrosis. The program involves three primary metabolisms... cisco networking salaryWebb28 juni 2024 · Ferroptosis is a new type of iron-dependent programmed cell death. ... proteomic sequencing analysis and OP-B administration showed the up-regulation of AURKA and down-regulation of PHKG2 and SLC7A5 in the 12-gene signature, indicating that OP-B induced NSCLC ferroptosis. Determination of malondialdehyde (MDA), … cisco network magic download

"Webb9 aug. 2024 · In this study, we constructed a 15-gene prognostic signature predicting overall survival based on ferroptosis-related genes (ferroptosis driver genes VDAC2, … " - Phkg2 ferroptosis

Phkg2 ferroptosis

Mechanisms of Ferroptosis and Relations With Regulated

Webb29 mars 2024 · PHKG2, IREB2, and CISD1 play an important role in ferroptosis by their function in iron metabolism balance. The phosphorylation of HSP27 induces ferroptosis resistance through blocking cytoskeleton-mediated iron absorption. EGLN1 can upregulate LSH expression by limiting HIF 1α. Webb31 aug. 2024 · A ferroptosis-related gene signature for overall survival prediction and immune infiltration in lung squamous cell carcinoma A ferroptosis-related gene signature was constructed to predict OS probability in LUSC. This could facilitate novel therapeutic methods and guide individualized therapy.

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Webb5 apr. 2024 · Ferroptosis-related gene is an iron-dependent regulatory tumor cell death, driven by the lethal accumulation of lipid peroxidation . Previous literature reported that … Webb23 mars 2024 · In conclusion, PHKG2 facilitates RSL3-induced ferroptosis in H. pylori-positive GC cells by promoting ALOX5 expression. These findings may contribute to a …

Webb30 juli 2024 · Ferroptosis is characterized by iron accumulation, excessive production of ROS, and lipid peroxidation. This illustration shows the process of ferroptosis, summarizing the key molecules and targets regulating iron and lipid peroxidation. Webb24 maj 2024 · Ferroptosis is a cell death process driven by damage to cell membranes and linked to numerous human diseases. Ferroptosis is caused by loss of activity of the key …

WebbNational Center for Biotechnology Information WebbCompendia expression profiles ?: GTEx compendium Human tissue compendium (Novartis) Global Cancer Map (Broad Institute) NCI-60 cell lines (National Cancer Institute): Advanced query: Further investigate these 64 genes : Gene families ?: Categorize these 64 genes by gene family : Show members (show 65 source identifiers mapped to 64 genes)

Webb20 mars 2024 · In conclusion, PHKG2 facilitates RSL3-induced ferroptosis in H. pylori-positive GC cells by promoting ALOX5 expression. These findings may contribute to a better understanding of the unique pathogenesis of H. pylori-induced GC and allow for maximum efficacy of genetic, cellular, and immune therapies for controlling ferroptosis …

Webbför 2 dagar sedan · In this study, we assume that deep learning model learns the nonlinear interaction between molecular environment (expression profile of ferroptosis regulators) and ferroptosis regulation score (potential regulation level of ferroptosis), so as to make accurate prediction. diamond scissors thetfordWebbAlthough some publications investigated the correlations between ferroptosis and LUAD, [10] [11][12][13] this study aimed to explore multi-omics data on LUAD including mRNA expression, protein ... diamond school addis ababaWebbWe identified PHKG2 as a crucial regulator of ferroptosis in H. pylori-positive GC. Its expression is correlated with patient survival and ICI therapeutic response. … diamond scissors sittingbourneWebb10 aug. 2024 · The small molecule RSL3 has been identified as an inducer of ferroptosis and its MoA, that involves binding and inhibition of GPX4 , was recently reported (Yang et al. 2014) as determined by affinity-based proteomics. GPX4 could also be inhibited upstream as a result of the inhibition of selenoprotein (SELT), for instance by directly … cisco networking storeWebbFerroptosis, a newly discovered iron-dependent form of cell death, contributes to various pathologies; however, the prognostic value of ferroptosis-related genes (FRGs) in cervical cancer (CC) remains unclear. Herein, we identified 15 differentially expressed FRGs based on data from The Cancer Genome Atlas database. diamond scissors readingWebb2 dec. 2024 · GPX4, system X c −, NRF2, p53, and UPS are the main ferroptosis regulators in lung cancer. Ferroptosis has a close relationship with the immune system status in lung cancer. The expression of ferroptosis-related genes including, ALOX15, PEBP1, GLS2, and PHKG2, positively predict prognosis. cisco networking training in kathmanduWebbFerroptosis, a novel type of programmed cell death, is different from the traditional cell death pathways such as ... which can oxidize PUFA by phosphorylating enzyme kinase G2 (PHKG2) -dependent iron pools through the diallyl site . Afterwards, AA-PE and AdA-PE catalyzed by LPCAT3 are oxidized by ALOX15 to generate LPO, leading to ... diamonds classical music song you tube